How to make cosmetic?

One of the first and most important steps in creating LIRENE products is scientific research done by the Experts of Lirene Science Laboratory in Scientific Research Centre.

In-vitro plays fundamental role in creating cosmetics. Examination of cosmetic ingredients (active substances) is done on isolated skin cells. This is the first stage of tests assessing usability of compounds for cosmetic products. It is crucial to investigate whether binding ingredients in complexes is beneficial for skin physiology, or quite the opposite. In-vitro research helps to assess whether cosmetic ingredients may harm cells when combined with other ones, and to decide which ingredients may work in synergy without causing any damages to skin cells. More complicated research is done on skin models. Nowadays the “artificial” skin models are indispensible in measuring permeability of active substances into the deeper layers of skin. Increasingly, the active substances are being encapsulated in special carriers with markers that help to determine the penetration depth – in other words, how deep into the cell the substance has gone.

Ex-vivo experiments are the next stage in creating cosmetics. They are based on evaluating the influence of ingredients and ready cosmetics on fragments of human skin in laboratory conditions. Such examinations prove that the active compounds contained in the cream have an actual influence on skin physiology.

In-vivo tests are done on ready cosmetic products prior to their launch on the market. The research is carried out on volunteers (probands) that are selected in terms of age and skin type.